How neural synchronization forms long-term memories in humans

Memories are stored within the synaptic connections between neural assemblies. These connections are being formed by synchronous firing, which is mediated by brain oscillations that can be recorded non-invasively in humans by means of MEG/EEG. Brain oscillations should thus be a key mechanism for the encoding of long-term memories. However, at the moment little is known about how these mechanisms work in the human brain. Therefore the goal of the proposed research plan is to investigate the role of neural synchronization for the formation of long-term memories in a series of experiments. Derived from cognitive theories of long-term memory, those experiments are aimed at dissociating synchronous memory networks at the time memories are being formed. Moreover it will be investigated, how the reactivation of those very same networks supports memory retrieval. By means of electrophysiological recordings (MEG/EEG) and functional brain imaging, the dynamics of oscillatory brain networks will be elucidated comprehensively. On the basis of these empirical data, a neuro-cognitive memory model will be delevoped, which incorporates the observed brain oscillatory dynamics. Moreover, neuroplasticity studies will be conducted to show how those networks are shaped by intense training. These may be valueable for the development of neurocognitive therapeutic interventions for memory disorders (e.g. dementia).